Overview
Top Medical Research Studies
Throughout our experiments, we observed that vitamin D treatment not only led to mitochondrial dysfunction but also suppressed the growth and spread of NSCLC cells. Specifically, we found that a significant increase in a particular tsRNA, known as tsRNA-07804, was linked to the decreased malignancy of these cancer cells.
Further investigations revealed that tsRNA-07804 works by targeting a protein called CRKL, which plays a role in promoting cancer cell survival. This interaction highlights how vitamin D can trigger apoptotic cell death in lung cancer. Our in vivo experiments mirrored these findings, showing reduced tumor growth in response to vitamin D treatment alongside increased tsRNA-07804 levels.
Overall, our research suggests that vitamin D can function as a therapeutic agent by enhancing the expression of tsRNA-07804, ultimately leading to suppressed NSCLC progression. This opens up new avenues for potential treatments in lung cancer patients.
We measured the expression of HRC and the vitamin D receptor (VDR) in lung cancer tissues compared to normal and adjacent non-cancerous tissues. Using various lab techniques, we assessed how vitamin D3 affects lung cancer cells, including their growth, spread, and ability to undergo programmed cell death, known as apoptosis.
Our findings revealed that vitamin D3 does inhibit the expression of HRC, which in turn decreased the migration and proliferation of lung cancer cells. Additionally, we noted an increase in the number of cells undergoing apoptosis in response to vitamin D3 treatment. In our animal model, mice treated with a vitamin D3 formulation exhibited smaller tumors and fewer cancerous cells than those treated with a combination of vitamin D3 and HRC.
Overall, our study indicates that vitamin D3 plays a protective role against lung cancer by downregulating HRC, thus slowing tumor growth and promoting cancer cell death.
By treating AM with vitamin D3, we observed improved stimulation of natural killer (NK) cells, which are crucial for targeting tumor cells. Additionally, when administered in aerosol form directly to the lungs of healthy mouse models, vitamin D3 significantly reduced metastatic growth of cancer cells.
The effects were promising, as our findings indicated that the immune cells in the lungs exhibited greater activation markers and enhanced ability to kill tumor cells when exposed to this treatment. This suggests that targeting vitamin D3 supplementation directly to the lungs could be a novel and effective approach to harness local immunity in combating lung cancer.
Most Useful Reviews
Medical Researches
- All Researches
The study tested the impact of vitamin D on various cancer cell lines, highlighting that H1299 and A549 cells were particularly responsive. Using techniques like the sulforhodamine-B assay, we discovered that vitamin D treatment significantly altered the expression of genes linked to cancer growth and spread, such as JAK2, STAT3, TGF-β, and SMAD4.
Moreover, when we combined vitamin D with cisplatin, there was a notable decrease in the activity of proteins associated with cancer cell migration and invasion. This combination therapy seems promising as it potentially targets the genes and proteins that enable lung cancer cells to thrive and spread. Overall, the results suggest that vitamin D could enhance the anticancer effects of cisplatin, opening doors for improved treatment strategies for lung cancer patients.
Throughout our experiments, we observed that vitamin D treatment not only led to mitochondrial dysfunction but also suppressed the growth and spread of NSCLC cells. Specifically, we found that a significant increase in a particular tsRNA, known as tsRNA-07804, was linked to the decreased malignancy of these cancer cells.
Further investigations revealed that tsRNA-07804 works by targeting a protein called CRKL, which plays a role in promoting cancer cell survival. This interaction highlights how vitamin D can trigger apoptotic cell death in lung cancer. Our in vivo experiments mirrored these findings, showing reduced tumor growth in response to vitamin D treatment alongside increased tsRNA-07804 levels.
Overall, our research suggests that vitamin D can function as a therapeutic agent by enhancing the expression of tsRNA-07804, ultimately leading to suppressed NSCLC progression. This opens up new avenues for potential treatments in lung cancer patients.
Our results indicated that for individuals with higher vitamin D consumption, there was a notable reduction in lung cancer cases. The odds ratio for lung cancer incidence was 0.88, suggesting a potential protective effect. However, when focusing only on randomized controlled trials, the association between vitamin D intake and cancer risk wasn’t significant, indicating that more robust studies could be needed to truly understand this relationship.
Overall, while we see promising evidence that suggests vitamin D may play a beneficial role in lowering lung cancer risk, particularly from observational studies, the randomized controlled trials did not provide substantial backing for this benefit. It’s crucial that we consider factors like cancer type and study design when interpreting these findings.
Our analysis revealed a significant connection between vitamin D levels and immune checkpoint receptors on T cells. Lower levels of vitamin D were associated with higher expressions of exhaustion markers like PD-1 and Tim-3, while higher vitamin D levels correlated with increased CD28 expression, an important marker for T cell activity.
When we looked into the mechanisms of how vitamin D3 works, we found that the active form of vitamin D promotes changes in T cells that help reduce their exhaustion. It does this by influencing specific genes and enhancing T cell function, leading to increased production of Th1 cytokines, which are crucial for effective immune responses against tumors.
Ultimately, we observed that vitamin D3 not only plays a role in improving the function of T cells but also seems to enhance their ability to combat tumor cells in lung cancer patients. This suggests that incorporating vitamin D3 into treatment regimens could potentially improve outcomes for those battling this disease.
We measured the expression of HRC and the vitamin D receptor (VDR) in lung cancer tissues compared to normal and adjacent non-cancerous tissues. Using various lab techniques, we assessed how vitamin D3 affects lung cancer cells, including their growth, spread, and ability to undergo programmed cell death, known as apoptosis.
Our findings revealed that vitamin D3 does inhibit the expression of HRC, which in turn decreased the migration and proliferation of lung cancer cells. Additionally, we noted an increase in the number of cells undergoing apoptosis in response to vitamin D3 treatment. In our animal model, mice treated with a vitamin D3 formulation exhibited smaller tumors and fewer cancerous cells than those treated with a combination of vitamin D3 and HRC.
Overall, our study indicates that vitamin D3 plays a protective role against lung cancer by downregulating HRC, thus slowing tumor growth and promoting cancer cell death.
User Reviews
- All Reviews
- Positive Reviews
- Negative Reviews
Frequently Asked Questions
Lung cancer is a type of cancer that begins in the lungs, which are vital organs located in the chest responsible for breathing and oxygen exchange. There are two primary types of lung cancer: non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). NSCLC accounts for about 85% of lung cancer cases and typically grows slower than SCLC, which is more aggressive and spreads quickly. Common risk factors for lung cancer include smoking, exposure to secondhand smoke, radon gas, and certain occupational hazards, making it essential to take preventive measures if you are at risk.
Symptoms of lung cancer can be subtle in the early stages, often including a persistent cough, chest pain, breathlessness, weight loss, and coughing up blood. Given that many individuals may not experience noticeable symptoms until the disease has progressed, regular check-ups and screenings are crucial, especially for those at higher risk. Treatment options for lung cancer may involve surgery, chemotherapy, radiation therapy, targeted therapy, or a combination of these approaches, depending on the cancer's type and stage. As research advances, new treatments are being developed, offering hope for improved survival rates and quality of life for those diagnosed.
Vitamin D is a fat-soluble vitamin that's essential for maintaining healthy bones and teeth, supporting immune system function, and facilitating normal cell growth and development. It plays a crucial role in calcium absorption in the gut, which is vital for bone health. Unlike most vitamins, our bodies can produce Vitamin D when exposed to sunlight, specifically UVB rays, which is why it’s often referred to as the "sunshine vitamin." However, depending on your geographical location, lifestyle, and skin type, getting sufficient Vitamin D from the sun alone can be challenging, particularly during the winter months.
In addition to sunlight, Vitamin D can be obtained from certain foods such as fatty fish (like salmon and mackerel), fish liver oils, and fortified foods like milk and cereals. Some individuals may also consider supplements, especially if they're at risk for deficiency. Insufficient vitamin D levels are linked to various health issues, including rickets in children, osteomalacia in adults, and even an increased risk of chronic diseases. Regularly checking your vitamin D levels and consulting with a healthcare professional can help ensure you're meeting your needs for optimal health.
Based on user reviews, the timeline for seeing results from this supplement can vary significantly. Some users report noticeable improvements after a period of around three months. For instance, one user has experienced increased energy, improved mood, and decreased fatigue almost three months after starting the supplement following their lung cancer diagnosis (Read Review). This suggests that if you're consistently taking the supplement, you might begin to observe benefits in approximately 12 weeks.
However, it's important to note that individual experiences can vary based on personal health conditions and dosage. For example, specific recommendations on dosage also play a crucial role; one user mentions their relative taking a substantial daily dosage of 5000IU, alongside recommendations for others to take 2000IU on non-consecutive days (Read Review). This variation indicates that while some may see results relatively quickly, others might take longer, particularly if their regimen differs. Overall, maintaining consistency is vital for maximizing the potential benefits.
The role of vitamin D in lung cancer treatment and outcomes is gaining traction in scientific research, with various studies highlighting its potential benefits. For instance, a study examined the effects of vitamin D supplementation alongside chemotherapy in lung cancer patients, indicating that vitamin D might alleviate some treatment-related side effects, particularly in non-small cell lung cancer (NSCLC) patients. Although this study suggested promising outcomes, the variability in methodologies across studies complicates direct comparisons (research-id='40004963').
Additionally, other studies have demonstrated that vitamin D can enhance the effectiveness of traditional cancer therapies, such as cisplatin, specifically targeting cancer cell pathways linked to growth and invasiveness (research-id='40059625'). Further evidence suggests that vitamin D levels may influence progression-free survival in lung cancer patients (research-id='38827521') and that high dietary intake of vitamin D is correlated with reduced lung cancer risk (research-id='37375626'). Overall, while the research is still developing, vitamin D shows promise as a supportive therapy in lung cancer treatment, potentially improving patient quality of life and treatment outcomes.
Based on user reviews, many individuals report various improvements in symptoms after incorporating vitamin D3 into their routines, particularly for those dealing with significant health challenges like lung cancer. One user noted that after almost three months of consistent use, they experienced increased energy, improved mood, and a decrease in fatigue despite the lingering uncertainty surrounding their quality of life following a lung cancer diagnosis (Read Review). This suggests potential benefits that may enhance well-being, particularly during challenging recovery periods.
Additionally, users emphasize the importance of vitamin D3 for health maintenance, especially in regions with limited sunlight exposure. One review highlighted that family members recovering from severe lung complications post-Covid saw improved recovery rates after using vitamin D3 as part of their treatment regimen (Read Review). While many users share positive anecdotal experiences, it's important to note that individual results can vary based on personal health circumstances and dosage, underscoring the necessity for tailored approaches to supplementation.
Users report that combining this vitamin D supplement with other treatments can be beneficial for individuals dealing with lung cancer. Many emphasize its importance in scenarios where access to sunlight is limited, particularly for patients who are unable to spend much time outdoors. For instance, one user noted their relatives with terminal lung cancer taking high daily doses of vitamin D3, under medical advice, to aid their overall health and recovery process (Read Review).
Furthermore, testimonials highlight the supplement's role in post-treatment recovery. A user mentioned administering vitamin D to their father and mother, both of whom had endured significant lung damage, and observed that it facilitated easier recovery during a subsequent illness (Read Review). These experiences suggest that users find complementary value in using this vitamin alongside other treatments, reinforcing its significance in maintaining health during and after lung cancer treatment.
Users report varying doses of Vitamin D for treating lung cancer, with some adhering to their doctors' specific recommendations. For instance, one user shared that their relatives with terminal lung cancer take 5000 IU daily, while their doctor suggested a lower dosage of 2000 IU on non-consecutive days, indicating a need for adaptable dosing based on individual conditions and medical advice (Read Review). Another user noted the importance of consistent intake, especially in cases where patients cannot access sunlight, which reinforces the idea that Vitamin D supplementation is particularly beneficial for lung cancer patients (Read Review).
Furthermore, users have highlighted the supplemental role of Vitamin D in recovery post-lung cancer treatment, suggesting its potential impact on overall health and quality of life. One individual found significant improvements in energy and mood after taking Vitamin D on their doctor's recommendation for nearly three months (Read Review). This indicates that appropriate dosing not only helps in treating lung cancer but may also aid recovery and enhance well-being after treatment.
References
- Effat H, Abohashem RS, Sharaky M, Mohammed MA. Vitamin D promotes anticancer effects of low-concentration cisplatin-treated non-small cell lung cancer cells via inhibiting the JAK2/STAT3 and TGF-β/SMAD4 pathways. Arch Pharm (Weinheim). 2025;358:e2400933. doi:10.1002/ardp.202400933
- Afonso ML, Capelas ML, Pimenta NM, Santos T, Mäkitie A, et al. A Systematic Review of Vitamin D Supplementation in Oncology: Chance of Science or Effectiveness?. Nutrients. 2025;17. doi:10.3390/nu17040634
- Helmy MW, Youssef MH, Yamari I, Amr A, Moussa FI, et al. Repurposing of sericin combined with dactolisib or vitamin D to combat non-small lung cancer cells through computational and biological investigations. Sci Rep. 2024;14:27034. doi:10.1038/s41598-024-76947-0
- Noronha V, Kolkur M, ArunKumar R, Adak S, Patil V, et al. The Impact of Baseline Vitamin D Level in Patients Receiving Gefitinib-Directed Therapy for EGFR-Mutant Non-Small-Cell Lung Cancer. Clin Med Insights Oncol. 2024;18:11795549241254460. doi:10.1177/11795549241254460
- Liang Y, Zhang X, Peng J, Liu J, Chen H, et al. Vitamin D-mediated tsRNA-07804 triggers mitochondrial dysfunction and suppresses non-small cell lung cancer progression by targeting CRKL. J Cancer Res Clin Oncol. 2024;150:51. doi:10.1007/s00432-023-05586-1
- Wierzbicka A, Semik-Gurgul E, Świątkiewicz M, Szmatoła T, Steg A, et al. Changes in DNA Methylation and mRNA Expression in Lung Tissue after Long-Term Supplementation with an Increased Dose of Cholecalciferol. Int J Mol Sci. 2023;25. doi:10.3390/ijms25010464
- Sha S, Chen LJ, Brenner H, Schöttker B. Associations of 25-hydroxyvitamin D status and vitamin D supplementation use with mortality due to 18 frequent cancer types in the UK Biobank cohort. Eur J Cancer. 2023;191:113241. doi:10.1016/j.ejca.2023.113241
- Arayici ME, Basbinar Y, Ellidokuz H. Vitamin D Intake, Serum 25-Hydroxyvitamin-D (25(OH)D) Levels, and Cancer Risk: A Comprehensive Meta-Meta-Analysis Including Meta-Analyses of Randomized Controlled Trials and Observational Epidemiological Studies. Nutrients. 2023;15. doi:10.3390/nu15122722
- Wierzbicka A, Semik-Gurgul E, Świątkiewicz M, Szmatoła T, Steg A, et al. Changes in DNA Methylation and mRNA Expression in Lung Tissue after Long-Term Supplementation with an Increased Dose of Cholecalciferol. Int J Mol Sci. 2023;25. doi:10.3390/ijms25010464
- Chen H, Zhu MZ, Wang XT, Ai M, Li SS, et al. 1,25(OH) D inhibits Lewis lung cancer cell migration via NHE1-sensitive metabolic reprograming. IUBMB Life. 2024;76:182. doi:10.1002/iub.2789
- Arayici ME, Basbinar Y, Ellidokuz H. Vitamin D Intake, Serum 25-Hydroxyvitamin-D (25(OH)D) Levels, and Cancer Risk: A Comprehensive Meta-Meta-Analysis Including Meta-Analyses of Randomized Controlled Trials and Observational Epidemiological Studies. Nutrients. 2023;15. doi:10.3390/nu15122722
- Li P, Zhu X, Cao G, Wu R, Li K, et al. 1α,25(OH)D reverses exhaustion and enhances antitumor immunity of human cytotoxic T cells. J Immunother Cancer. 2022;10. doi:10.1136/jitc-2021-003477
- Jia Z, Wang K, Duan Y, Hu K, Zhang Y, et al. Claudin1 decrease induced by 1,25-dihydroxy-vitamin D3 potentiates gefitinib resistance therapy through inhibiting AKT activation-mediated cancer stem-like properties in NSCLC cells. Cell Death Discov. 2022;8:122. doi:10.1038/s41420-022-00918-5
- Yiyan S, Yang S, Li D, Li W. Vitamin D Affects the Warburg Effect and Stemness Maintenance of Non- Small-Cell Lung Cancer Cells by Regulating the PI3K/AKT/mTOR Signaling Pathway. Curr Cancer Drug Targets. 2022;22:86. doi:10.2174/1568009621666210729100300
- Lawson C, Ferreira V, Carli F, Chevalier S. Effects of multimodal prehabilitation on muscle size, myosteatosis, and dietary intake of surgical patients with lung cancer - a randomized feasibility study. Appl Physiol Nutr Metab. 2021;46:1407. doi:10.1139/apnm-2021-0249
- Ai M, Li SS, Chen H, Wang XT, Sun JN, et al. 1,25(OH) D attenuates sleep disturbance in mouse models of Lewis lung cancer, in silico and in vivo. J Cell Physiol. 2021;236:7473. doi:10.1002/jcp.30458
- Liu N, Li X, Fu Y, Li Y, Lu W, et al. Inhibition of lung cancer by vitamin D depends on downregulation of histidine-rich calcium-binding protein. J Adv Res. 2021;29:13. doi:10.1016/j.jare.2020.08.013
- Bianchi F, Sommariva M, Le Noci V, Camelliti S, Gagliano N, et al. Aerosol 1,25-dihydroxyvitamin D3 supplementation: A strategy to boost anti-tumor innate immune activity. PLoS One. 2021;16:e0248789. doi:10.1371/journal.pone.0248789
- Maj E, Maj B, Bobak K, Gos M, Chodyński M, et al. Differential Response of Lung Cancer Cells, with Various Driver Mutations, to Plant Polyphenol Resveratrol and Vitamin D Active Metabolite PRI-2191. Int J Mol Sci. 2021;22. doi:10.3390/ijms22052354
