Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.6
USERS' SCORE
Good
Based on 4 Reviews
8.2
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
50 mcg (2,000 IU)
250%
Top Medical Research Studies
9
We explored the impact of vitamin D treatment on non-small cell lung cancer (NSCLC) and how it may influence mitochondrial functions in cancer cells. By utilizing small RNA sequencing, we identified various tRNA-derived small RNAs (tsRNAs) that were differentially expressed in lung cancer cells treated with vitamin D.
Throughout our experiments, we observed that vitamin D treatment not only led to mitochondrial dysfunction but also suppressed the growth and spread of NSCLC cells. Specifically, we found that a significant increase in a particular tsRNA, known as tsRNA-07804, was linked to the decreased malignancy of these cancer cells.
Further investigations revealed that tsRNA-07804 works by targeting a protein called CRKL, which plays a role in promoting cancer cell survival. This interaction highlights how vitamin D can trigger apoptotic cell death in lung cancer. Our in vivo experiments mirrored these findings, showing reduced tumor growth in response to vitamin D treatment alongside increased tsRNA-07804 levels.
Overall, our research suggests that vitamin D can function as a therapeutic agent by enhancing the expression of tsRNA-07804, ultimately leading to suppressed NSCLC progression. This opens up new avenues for potential treatments in lung cancer patients.
Throughout our experiments, we observed that vitamin D treatment not only led to mitochondrial dysfunction but also suppressed the growth and spread of NSCLC cells. Specifically, we found that a significant increase in a particular tsRNA, known as tsRNA-07804, was linked to the decreased malignancy of these cancer cells.
Further investigations revealed that tsRNA-07804 works by targeting a protein called CRKL, which plays a role in promoting cancer cell survival. This interaction highlights how vitamin D can trigger apoptotic cell death in lung cancer. Our in vivo experiments mirrored these findings, showing reduced tumor growth in response to vitamin D treatment alongside increased tsRNA-07804 levels.
Overall, our research suggests that vitamin D can function as a therapeutic agent by enhancing the expression of tsRNA-07804, ultimately leading to suppressed NSCLC progression. This opens up new avenues for potential treatments in lung cancer patients.
Read More
9
We conducted a study to understand how vitamin D3 influences lung cancer, particularly focusing on a protein known as histidine-rich calcium-binding protein (HRC). Our research explored whether vitamin D3 could help lower HRC levels, given its crucial role in calcium balance, which is significant in cancer development.
We measured the expression of HRC and the vitamin D receptor (VDR) in lung cancer tissues compared to normal and adjacent non-cancerous tissues. Using various lab techniques, we assessed how vitamin D3 affects lung cancer cells, including their growth, spread, and ability to undergo programmed cell death, known as apoptosis.
Our findings revealed that vitamin D3 does inhibit the expression of HRC, which in turn decreased the migration and proliferation of lung cancer cells. Additionally, we noted an increase in the number of cells undergoing apoptosis in response to vitamin D3 treatment. In our animal model, mice treated with a vitamin D3 formulation exhibited smaller tumors and fewer cancerous cells than those treated with a combination of vitamin D3 and HRC.
Overall, our study indicates that vitamin D3 plays a protective role against lung cancer by downregulating HRC, thus slowing tumor growth and promoting cancer cell death.
We measured the expression of HRC and the vitamin D receptor (VDR) in lung cancer tissues compared to normal and adjacent non-cancerous tissues. Using various lab techniques, we assessed how vitamin D3 affects lung cancer cells, including their growth, spread, and ability to undergo programmed cell death, known as apoptosis.
Our findings revealed that vitamin D3 does inhibit the expression of HRC, which in turn decreased the migration and proliferation of lung cancer cells. Additionally, we noted an increase in the number of cells undergoing apoptosis in response to vitamin D3 treatment. In our animal model, mice treated with a vitamin D3 formulation exhibited smaller tumors and fewer cancerous cells than those treated with a combination of vitamin D3 and HRC.
Overall, our study indicates that vitamin D3 plays a protective role against lung cancer by downregulating HRC, thus slowing tumor growth and promoting cancer cell death.
Read More
9
We explored the potential of aerosolized 1,25-dihydroxyvitamin D3, also known as vitamin D3, to enhance immune responses against lung cancer. This study focused on its ability to shift alveolar macrophages (AM) toward a more cancer-fighting role in the presence of lung metastases from tumors like MC-38 colon carcinoma and B16 melanoma.
By treating AM with vitamin D3, we observed improved stimulation of natural killer (NK) cells, which are crucial for targeting tumor cells. Additionally, when administered in aerosol form directly to the lungs of healthy mouse models, vitamin D3 significantly reduced metastatic growth of cancer cells.
The effects were promising, as our findings indicated that the immune cells in the lungs exhibited greater activation markers and enhanced ability to kill tumor cells when exposed to this treatment. This suggests that targeting vitamin D3 supplementation directly to the lungs could be a novel and effective approach to harness local immunity in combating lung cancer.
By treating AM with vitamin D3, we observed improved stimulation of natural killer (NK) cells, which are crucial for targeting tumor cells. Additionally, when administered in aerosol form directly to the lungs of healthy mouse models, vitamin D3 significantly reduced metastatic growth of cancer cells.
The effects were promising, as our findings indicated that the immune cells in the lungs exhibited greater activation markers and enhanced ability to kill tumor cells when exposed to this treatment. This suggests that targeting vitamin D3 supplementation directly to the lungs could be a novel and effective approach to harness local immunity in combating lung cancer.
Read More
Most Useful Reviews
9
Vital for survival
11 people found this helpful
I am consistently taking this vitamin D due to late-stage lung cancer. It’s crucial as I cannot access sunlight much.
Read More
4
Essential for health
6 people found this helpful
This vitamin D3 is important for those in Taiwan who struggle to get sunlight, particularly for lung cancer patients. My relatives with terminal lung cancer take 5000IU daily, while my doctor suggested 2000IU on non-consecutive days. I believe D3 is crucial for post-cancer health maintenance.
Read More
7.5
Post-Covid recovery
I administered this vitamin as maintenance for my 65-year-old father post-lung cancer treatment after Covid, where he had 75% lung damage. My mother took it as well after suffering a 45% loss. They recovered from the virus much more easily the second time. I appreciate the once-a-day dosage.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.6
- All Researches
9
Vitamin D and cisplatin synergy
We explored whether adding vitamin D to cisplatin treatment could be a more effective strategy against non-small cell lung cancer (NSCLC). This research focused on how these treatments affect certain critical cellular pathways involved in cancer progression.
The study tested the impact of vitamin D on various cancer cell lines, highlighting that H1299 and A549 cells were particularly responsive. Using techniques like the sulforhodamine-B assay, we discovered that vitamin D treatment significantly altered the expression of genes linked to cancer growth and spread, such as JAK2, STAT3, TGF-β, and SMAD4.
Moreover, when we combined vitamin D with cisplatin, there was a notable decrease in the activity of proteins associated with cancer cell migration and invasion. This combination therapy seems promising as it potentially targets the genes and proteins that enable lung cancer cells to thrive and spread. Overall, the results suggest that vitamin D could enhance the anticancer effects of cisplatin, opening doors for improved treatment strategies for lung cancer patients.
The study tested the impact of vitamin D on various cancer cell lines, highlighting that H1299 and A549 cells were particularly responsive. Using techniques like the sulforhodamine-B assay, we discovered that vitamin D treatment significantly altered the expression of genes linked to cancer growth and spread, such as JAK2, STAT3, TGF-β, and SMAD4.
Moreover, when we combined vitamin D with cisplatin, there was a notable decrease in the activity of proteins associated with cancer cell migration and invasion. This combination therapy seems promising as it potentially targets the genes and proteins that enable lung cancer cells to thrive and spread. Overall, the results suggest that vitamin D could enhance the anticancer effects of cisplatin, opening doors for improved treatment strategies for lung cancer patients.
Read More
9
We explored the impact of vitamin D treatment on non-small cell lung cancer (NSCLC) and how it may influence mitochondrial functions in cancer cells. By utilizing small RNA sequencing, we identified various tRNA-derived small RNAs (tsRNAs) that were differentially expressed in lung cancer cells treated with vitamin D.
Throughout our experiments, we observed that vitamin D treatment not only led to mitochondrial dysfunction but also suppressed the growth and spread of NSCLC cells. Specifically, we found that a significant increase in a particular tsRNA, known as tsRNA-07804, was linked to the decreased malignancy of these cancer cells.
Further investigations revealed that tsRNA-07804 works by targeting a protein called CRKL, which plays a role in promoting cancer cell survival. This interaction highlights how vitamin D can trigger apoptotic cell death in lung cancer. Our in vivo experiments mirrored these findings, showing reduced tumor growth in response to vitamin D treatment alongside increased tsRNA-07804 levels.
Overall, our research suggests that vitamin D can function as a therapeutic agent by enhancing the expression of tsRNA-07804, ultimately leading to suppressed NSCLC progression. This opens up new avenues for potential treatments in lung cancer patients.
Throughout our experiments, we observed that vitamin D treatment not only led to mitochondrial dysfunction but also suppressed the growth and spread of NSCLC cells. Specifically, we found that a significant increase in a particular tsRNA, known as tsRNA-07804, was linked to the decreased malignancy of these cancer cells.
Further investigations revealed that tsRNA-07804 works by targeting a protein called CRKL, which plays a role in promoting cancer cell survival. This interaction highlights how vitamin D can trigger apoptotic cell death in lung cancer. Our in vivo experiments mirrored these findings, showing reduced tumor growth in response to vitamin D treatment alongside increased tsRNA-07804 levels.
Overall, our research suggests that vitamin D can function as a therapeutic agent by enhancing the expression of tsRNA-07804, ultimately leading to suppressed NSCLC progression. This opens up new avenues for potential treatments in lung cancer patients.
Read More
9
Vitamin D's potential in lung cancer
We analyzed various studies examining how vitamin D affects lung cancer, specifically looking at both vitamin D intake and serum levels of 25-hydroxyvitamin D. The findings from 35 eligible meta-analyses revealed a strong link between higher vitamin D intake and reduced lung cancer risk, particularly showing a significant decrease in incidence rates.
Our results indicated that for individuals with higher vitamin D consumption, there was a notable reduction in lung cancer cases. The odds ratio for lung cancer incidence was 0.88, suggesting a potential protective effect. However, when focusing only on randomized controlled trials, the association between vitamin D intake and cancer risk wasn’t significant, indicating that more robust studies could be needed to truly understand this relationship.
Overall, while we see promising evidence that suggests vitamin D may play a beneficial role in lowering lung cancer risk, particularly from observational studies, the randomized controlled trials did not provide substantial backing for this benefit. It’s crucial that we consider factors like cancer type and study design when interpreting these findings.
Our results indicated that for individuals with higher vitamin D consumption, there was a notable reduction in lung cancer cases. The odds ratio for lung cancer incidence was 0.88, suggesting a potential protective effect. However, when focusing only on randomized controlled trials, the association between vitamin D intake and cancer risk wasn’t significant, indicating that more robust studies could be needed to truly understand this relationship.
Overall, while we see promising evidence that suggests vitamin D may play a beneficial role in lowering lung cancer risk, particularly from observational studies, the randomized controlled trials did not provide substantial backing for this benefit. It’s crucial that we consider factors like cancer type and study design when interpreting these findings.
Read More
9
We explored the potential role of vitamin D3 in lung cancer patients and its effects on the immune system, specifically focusing on T cells. The research involved 172 patients undergoing treatment for non-small cell lung cancer (NSCLC). These patients received standard chemotherapy and were then given varying doses of vitamin D3 for three weeks.
Our analysis revealed a significant connection between vitamin D levels and immune checkpoint receptors on T cells. Lower levels of vitamin D were associated with higher expressions of exhaustion markers like PD-1 and Tim-3, while higher vitamin D levels correlated with increased CD28 expression, an important marker for T cell activity.
When we looked into the mechanisms of how vitamin D3 works, we found that the active form of vitamin D promotes changes in T cells that help reduce their exhaustion. It does this by influencing specific genes and enhancing T cell function, leading to increased production of Th1 cytokines, which are crucial for effective immune responses against tumors.
Ultimately, we observed that vitamin D3 not only plays a role in improving the function of T cells but also seems to enhance their ability to combat tumor cells in lung cancer patients. This suggests that incorporating vitamin D3 into treatment regimens could potentially improve outcomes for those battling this disease.
Our analysis revealed a significant connection between vitamin D levels and immune checkpoint receptors on T cells. Lower levels of vitamin D were associated with higher expressions of exhaustion markers like PD-1 and Tim-3, while higher vitamin D levels correlated with increased CD28 expression, an important marker for T cell activity.
When we looked into the mechanisms of how vitamin D3 works, we found that the active form of vitamin D promotes changes in T cells that help reduce their exhaustion. It does this by influencing specific genes and enhancing T cell function, leading to increased production of Th1 cytokines, which are crucial for effective immune responses against tumors.
Ultimately, we observed that vitamin D3 not only plays a role in improving the function of T cells but also seems to enhance their ability to combat tumor cells in lung cancer patients. This suggests that incorporating vitamin D3 into treatment regimens could potentially improve outcomes for those battling this disease.
Read More
9
We conducted a study to understand how vitamin D3 influences lung cancer, particularly focusing on a protein known as histidine-rich calcium-binding protein (HRC). Our research explored whether vitamin D3 could help lower HRC levels, given its crucial role in calcium balance, which is significant in cancer development.
We measured the expression of HRC and the vitamin D receptor (VDR) in lung cancer tissues compared to normal and adjacent non-cancerous tissues. Using various lab techniques, we assessed how vitamin D3 affects lung cancer cells, including their growth, spread, and ability to undergo programmed cell death, known as apoptosis.
Our findings revealed that vitamin D3 does inhibit the expression of HRC, which in turn decreased the migration and proliferation of lung cancer cells. Additionally, we noted an increase in the number of cells undergoing apoptosis in response to vitamin D3 treatment. In our animal model, mice treated with a vitamin D3 formulation exhibited smaller tumors and fewer cancerous cells than those treated with a combination of vitamin D3 and HRC.
Overall, our study indicates that vitamin D3 plays a protective role against lung cancer by downregulating HRC, thus slowing tumor growth and promoting cancer cell death.
We measured the expression of HRC and the vitamin D receptor (VDR) in lung cancer tissues compared to normal and adjacent non-cancerous tissues. Using various lab techniques, we assessed how vitamin D3 affects lung cancer cells, including their growth, spread, and ability to undergo programmed cell death, known as apoptosis.
Our findings revealed that vitamin D3 does inhibit the expression of HRC, which in turn decreased the migration and proliferation of lung cancer cells. Additionally, we noted an increase in the number of cells undergoing apoptosis in response to vitamin D3 treatment. In our animal model, mice treated with a vitamin D3 formulation exhibited smaller tumors and fewer cancerous cells than those treated with a combination of vitamin D3 and HRC.
Overall, our study indicates that vitamin D3 plays a protective role against lung cancer by downregulating HRC, thus slowing tumor growth and promoting cancer cell death.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Vital for survival
11 people found this helpful
I am consistently taking this vitamin D due to late-stage lung cancer. It’s crucial as I cannot access sunlight much.
Read More
4
Essential for health
6 people found this helpful
This vitamin D3 is important for those in Taiwan who struggle to get sunlight, particularly for lung cancer patients. My relatives with terminal lung cancer take 5000IU daily, while my doctor suggested 2000IU on non-consecutive days. I believe D3 is crucial for post-cancer health maintenance.
Read More
7.5
Post-Covid recovery
I administered this vitamin as maintenance for my 65-year-old father post-lung cancer treatment after Covid, where he had 75% lung damage. My mother took it as well after suffering a 45% loss. They recovered from the virus much more easily the second time. I appreciate the once-a-day dosage.
Read More
7.5
Increased energy noted
97 people found this helpful
I've been taking this vitamin since my lung cancer diagnosis on my doctor's recommendation. After almost 3 months, I have noticed increased energy and mood along with a decrease in fatigue. My quality of life remains uncertain, but improvements have been significant.
Read More
Frequently Asked Questions
7.5
Increased energy noted
97 people found this helpful
I've been taking this vitamin since my lung cancer diagnosis on my doctor's recommendation. After almost 3 months, I have noticed increased energy and mood along with a decrease in fatigue. My quality of life remains uncertain, but improvements have been significant.
4
Essential for health
6 people found this helpful
This vitamin D3 is important for those in Taiwan who struggle to get sunlight, particularly for lung cancer patients. My relatives with terminal lung cancer take 5000IU daily, while my doctor suggested 2000IU on non-consecutive days. I believe D3 is crucial for post-cancer health maintenance.
7.5
Post-Covid recovery
I administered this vitamin as maintenance for my 65-year-old father post-lung cancer treatment after Covid, where he had 75% lung damage. My mother took it as well after suffering a 45% loss. They recovered from the virus much more easily the second time. I appreciate the once-a-day dosage.
9
Vital for survival
11 people found this helpful
I am consistently taking this vitamin D due to late-stage lung cancer. It’s crucial as I cannot access sunlight much.
References
- Effat H, Abohashem RS, Sharaky M, Mohammed MA. Vitamin D promotes anticancer effects of low-concentration cisplatin-treated non-small cell lung cancer cells via inhibiting the JAK2/STAT3 and TGF-β/SMAD4 pathways. Arch Pharm (Weinheim). 2025;358:e2400933. 10.1002/ardp.202400933
- Afonso ML, Capelas ML, Pimenta NM, Santos T, Mäkitie A, et al. A Systematic Review of Vitamin D Supplementation in Oncology: Chance of Science or Effectiveness?. Nutrients. 2025;17. 10.3390/nu17040634
- Helmy MW, Youssef MH, Yamari I, Amr A, Moussa FI, et al. Repurposing of sericin combined with dactolisib or vitamin D to combat non-small lung cancer cells through computational and biological investigations. Sci Rep. 2024;14:27034. 10.1038/s41598-024-76947-0
- Noronha V, Kolkur M, ArunKumar R, Adak S, Patil V, et al. The Impact of Baseline Vitamin D Level in Patients Receiving Gefitinib-Directed Therapy for EGFR-Mutant Non-Small-Cell Lung Cancer. Clin Med Insights Oncol. 2024;18:11795549241254460. 10.1177/11795549241254460
- Liang Y, Zhang X, Peng J, Liu J, Chen H, et al. Vitamin D-mediated tsRNA-07804 triggers mitochondrial dysfunction and suppresses non-small cell lung cancer progression by targeting CRKL. J Cancer Res Clin Oncol. 2024;150:51. 10.1007/s00432-023-05586-1
- Wierzbicka A, Semik-Gurgul E, Świątkiewicz M, Szmatoła T, Steg A, et al. Changes in DNA Methylation and mRNA Expression in Lung Tissue after Long-Term Supplementation with an Increased Dose of Cholecalciferol. Int J Mol Sci. 2023;25. 10.3390/ijms25010464
- Sha S, Chen LJ, Brenner H, Schöttker B. Associations of 25-hydroxyvitamin D status and vitamin D supplementation use with mortality due to 18 frequent cancer types in the UK Biobank cohort. Eur J Cancer. 2023;191:113241. 10.1016/j.ejca.2023.113241
- Arayici ME, Basbinar Y, Ellidokuz H. Vitamin D Intake, Serum 25-Hydroxyvitamin-D (25(OH)D) Levels, and Cancer Risk: A Comprehensive Meta-Meta-Analysis Including Meta-Analyses of Randomized Controlled Trials and Observational Epidemiological Studies. Nutrients. 2023;15. 10.3390/nu15122722
- Chen H, Zhu MZ, Wang XT, Ai M, Li SS, et al. 1,25(OH) D inhibits Lewis lung cancer cell migration via NHE1-sensitive metabolic reprograming. IUBMB Life. 2024;76:182. 10.1002/iub.2789
- Li P, Zhu X, Cao G, Wu R, Li K, et al. 1α,25(OH)D reverses exhaustion and enhances antitumor immunity of human cytotoxic T cells. J Immunother Cancer. 2022;10. 10.1136/jitc-2021-003477
- Jia Z, Wang K, Duan Y, Hu K, Zhang Y, et al. Claudin1 decrease induced by 1,25-dihydroxy-vitamin D3 potentiates gefitinib resistance therapy through inhibiting AKT activation-mediated cancer stem-like properties in NSCLC cells. Cell Death Discov. 2022;8:122. 10.1038/s41420-022-00918-5
- Yiyan S, Yang S, Li D, Li W. Vitamin D Affects the Warburg Effect and Stemness Maintenance of Non- Small-Cell Lung Cancer Cells by Regulating the PI3K/AKT/mTOR Signaling Pathway. Curr Cancer Drug Targets. 2022;22:86. 10.2174/1568009621666210729100300
- Lawson C, Ferreira V, Carli F, Chevalier S. Effects of multimodal prehabilitation on muscle size, myosteatosis, and dietary intake of surgical patients with lung cancer - a randomized feasibility study. Appl Physiol Nutr Metab. 2021;46:1407. 10.1139/apnm-2021-0249
- Ai M, Li SS, Chen H, Wang XT, Sun JN, et al. 1,25(OH) D attenuates sleep disturbance in mouse models of Lewis lung cancer, in silico and in vivo. J Cell Physiol. 2021;236:7473. 10.1002/jcp.30458
- Liu N, Li X, Fu Y, Li Y, Lu W, et al. Inhibition of lung cancer by vitamin D depends on downregulation of histidine-rich calcium-binding protein. J Adv Res. 2021;29:13. 10.1016/j.jare.2020.08.013
- Bianchi F, Sommariva M, Le Noci V, Camelliti S, Gagliano N, et al. Aerosol 1,25-dihydroxyvitamin D3 supplementation: A strategy to boost anti-tumor innate immune activity. PLoS One. 2021;16:e0248789. 10.1371/journal.pone.0248789
- Maj E, Maj B, Bobak K, Gos M, Chodyński M, et al. Differential Response of Lung Cancer Cells, with Various Driver Mutations, to Plant Polyphenol Resveratrol and Vitamin D Active Metabolite PRI-2191. Int J Mol Sci. 2021;22. 10.3390/ijms22052354
